Injury: Jones fracture. Expected return: Two to three weeks. J Urol. Lancet. The A Jones fracture is a type of fracture in your foot. Gallup was again a limited participant in practice this week but progressed to seven-on-seven drills after doing only individual drills last week. And it was reported on Monday evening that the Colombian will now be sidelined for six weeks, meaning he wont be back available until after the World Cup. PSA decline, defined as >50% and >90% decline from baseline, favored enzalutamide (enzalutamide: 91% versus bicalutamide: 42% and enzalutamide: 76% versus bicalutamide: 12%, respectively). Sipuleucel-T is an immunotherapy for the management of mCRPC. ------------------------------------ Dorance Armstrong, Height: 6-4Weight: 255 lbsCollege: Kansas. Men receiving zoledronic acid had significantly lower rates of SREs (33% with zoledronic acid versus 44% with placebo; P=0.021) and longer time to first SRE (>410 days with zoledronic acid and 321 days with placebo; P=0.011). McGovern limped off the field with help from the Cowboys' athletic training staff, but soon returned to the sideline testing out the ankle. "Not yet. Lancet Oncol 2016; Ryan CJ, Crawford ED, Shore ND et al: The IMAAGEN study: effect of abiraterone acetate and prednisone on prostate specific antigen and radiographic disease progression in patients with nonmetastatic castration resistant prostate cancer. Surgery is also used for people who use their hands for minute motor skills, such as playing the piano. 10:41 p.m. - What a big game for the rookie cornerback, who picked off two passes in the second half as the Cowboys rolled past the Colts. But just how difficult was it for him to put forth this impressive, comeback season? PARP inhibitors leverage defects in DNA repair to provide a survival advantage in men with mCRPC who have mutations in DNA repair enzymes central to homologous recombination DNA repair. Median survival in the sipuleucel-T arm was 25.8 months compared to 21.7 months in the placebo arm. 11:01 a.m. - The determination on when Jason Peters will make his debut for the Cowboys remains rooted in how quickly he can both reacclimate to the rigors of regular season football - having participated in no training camp reps for any club - and his acclimation to the offensive scheme and personnel in Dallas. 6 p.m. - Despite a late-week neck issue that landed him on Friday's injury report, Cowboys starting safety Jayron Kearse is active for Sunday's season opener against the Tampa Bay Buccaneers. Cancer 2017; Rodrigues DN, Rescigno P, Liu D et al: Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer. 12:46 a.m. - Jayron Kearse exited the Cowboys home opener with a knee injury that needs to be further evaluated, but the good news for the safety unit in Dallas is they're deeper than they have been in several years and that was evidenced by Donovan Wilson in Week 1 against Tom Brady and the Buccaneers. Germline mutations in genes involved in DNA damage repair (DDR) have been identified in over 11.8% of men with metastatic prostate cancer, with the most commonly identified gene mutations being BRCA2, CHEK2, ATM, and BRCA1.80 Germline mutations have been found to portend poor prognosis among men with metastatic prostate cancer. Yet, Jalen Tolbert was no active for Sunday's game with the Bucs, passed over by an undrafted rookie and a fifth-round pick from last year. Cox is joined on this week's inactives by Will Grier, Nahshon Wright, Markquese Bell and Quinton Bohanna. In May 2017, the FDA approved pembrolizumab for patients with any metastatic, MSI-H or dMMR histology that have progressed following prior treatment and who have no satisfactory alternative treatment options.133. Eur Urol 1998; Armstrong AJ, Szmulewitz RZ, Petrylak DP et al: ARCHES: a randomized, phase III study of androgen deprivation therapy with enzalutamide or placebo in men with metastatic hormone-sensitive prostate cancer. PSADT should be calculated for men with a rising PSA in the setting of ongoing ADT (castration-resistance) as PSADT is useful in determining which men are at highest risk of developing metastatic lesions or dying from prostate cancer.104PSADT <10 months was used to identify the highest risk population for inclusion in the three trials that led to approval of the AR antagonists for men with nmCRPC and is recommended to consider when adding one of the medications to ADT in men with nmCRPC. Rush is certainly no stranger to the role, having eventually earned the nod after joining the club as an undrafted free agent in 2017 and proving he was a viable option. The HR for death of men treated with cabazitaxel compared with those taking mitoxantrone was 0.70 (95%CI 0.59 to 0.83, p<0.0001). If Morant doesnt end up being activated for Tuesdays contest, hell get a couple extra days off before Memphis hosts New Orleans on Friday night, so hed be well positioned to play in that game. The combination of no known benefit with known and potentially serious harms supports the decision to recommend against use of these agents in men with nmCRPC. The availability of Joseph adds depth to a cornerback room that is readying to face Tom Brady and his stable of offensive weapons on Sunday evening, and while it's unclear how much Joseph would be tasked with doing in Week 1 - he'd become one more tool in the toolbox of Dan Quinn (assuming no setbacks between now and game day). With his pre-season ending prematurely and no competitive minutes since March 20, its likely Oxlade-Chamberlain is not seen on the pitch until after the World Cup concludes. Clin Nucl Med 2017; Emmett L, van Leeuwen PJ, Nandurkar R et al: Treatment outcomes from 68Ga-PSMA PET/CT-informed salvage radiation treatment in men with rising PSA after radical prostatectomy: prognostic value of a negative PSMA PET. 3:00 p.m. - Things are looking much healthier for the Dallas Cowboys as they near kickoff against the Indianapolis Colts for Sunday night. "Michael's done an excellent job of hitting those (injury rehab) targets and I think we're kind of in the final stages here," head coach Mike McCarthy said. J Clin Oncol 2017; NUBEQA (darolutamide) plus androgen deprivation therapy achieved the secondary endpoint of overall survival (OS) in men with non-metastatic castration-resistant prostate cancer. Plus, watch live games, clips and highlights for your favorite teams! As things get underway on Wednesday, Lewis will again be a full go in practice - a strong sign he experienced no setbacks following Monday's work. The use of sipuleucel-T immunotherapy is not recommended in symptomatic disease that necessitates opioid use, consistent with the FDA indication for this approach. Per ESPN, he smiles and says, "We'll see how this week goes.". J Clin Oncol 2019; Ryan CJ, Smith MR, Fizazi K et al: Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study. The Cowboys would need to start his 21-day practice window this week, meaning Washington would have three weeks before he could return to active roster. N Engl J Med 2011; Kantoff PW, Higano CS, Shore ND et al: Sipuleucel-T immunotherapy for castration-resistant prostate cancer. Cohort A had at least one alteration in BRCA1, BRCA2, or ATM; and cohort B had alterations in any of 12 other prespecified genes (BRIP1, BARD1, CDK12, CHEK1, CHEK2, FANCL, PALB2, PPP2R2A, RAD51B, RAD51C, RAD51D, or RAD54L). Recommendations include weight bearing exercises, muscle building exercises, balance exercises, smoking cessation, reduction of alcohol intake, and adequate intake of calcium and vitamin D.144The estimated daily calcium requirement is 1,000 mg to 1,200 mg from food and supplements. DePaul University does not discriminate on the basis of race, color, ethnicity, religion, sex, gender, gender identity, sexual orientation, national origin, age, marital status, pregnancy, parental status, family relationship status, physical or mental disability, military status, genetic information or other status protected So far, Henry hasn't been impacted much by his injury in 2022. Presented by Blockchain.com, Height: 6-0Weight: 197 lbsCollege: Fresno State. It obviously feels good [to get the nod].". We're very familiar with him. Lancet 2018; Antonarakis ES, Feng Z, Trock BJ et al: The natural history of metastatic progression in men with prostate-specific antigen recurrence after radical prostatectomy: long-term follow-up. In the TOPARP-A trial, heavily-treated mCRPC patients treated with olaparib were much more likely to respond in the setting of a DDR alteration.39 The response rate was 88% in biomarker positive patients and 6% in biomarker negative patients. However, for most patients, it is reasonable to inform patients about the tenets of bone health based on bone physiology, expert opinion, and syntheses of available clinical evidence.144, The United States National Osteoporosis Foundation provides easy to use recommendations for bone health maintenance ( https://www.nof.org/preventing-fractures/prevention/). But we don't have a timeframe (for his return). Sipuleucel-T is not associated with objective anti-tumor activity; its use is not appropriate for patients with large tumor burdens, those with visceral disease or with rapidly progressive disease. These trials are ongoing, and at present the use of surgery should be considered investigational and only conducted within the context of a trial. The cutdown from 80 players to the mandatory count of 53 must happen today, but it's unclear which positions will run rich on the roster and which will run lean, although owner and general manager Jerry Jones did give insight into which category the defensive line will likely fall into. We'll see how he works this week. The club opted not to keep him on the Physically Unable to Perform list, which would have meant a minimum four-game absence on PUP. Thus, it seems like that was more of a load management situation than anything else. Harris RP, Helfand M, Woolf SH et al: Current methods of the US Preventive Services Task Force: a review of the process. N Engl J Med 2015; James ND, Sydes MR, Clarke NW et al: Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial. BJU Int 2017; Kim KH, Han KS, Kim KH et al: The prognostic effect of prostate-specific antigen half-life at the first follow-up visit in newly diagnosed metastatic prostate cancer. Jonathan Taylor likely The veteran receiver made an appearance at Cowboys practice on Wednesday - doing rehab work off to the side on resistance bands - with no visible aid on his surgically-repaired foot. Its hard. In TAX-327,19 26% of patients in the docetaxel plus prednisone every three weeks arm had one or more serious adverse events, and roughly 11% of patients in this group discontinued treatment due to adverse events. Just keep getting better every day.". With compelling level A evidence supporting the use of docetaxel, abiraterone acetate plus prednisone, apalutamide, or enzalutamide in combination with ADT in men with newly diagnosed mHSPC, the Panel believes that long-term use of first generation antiandrogens bicalutamide, flutamide, nilutamide in lieu of the above noted agents cannot be supported. However, Morant appears to be on the verge of returning after missing only Sundays game in Brooklyn. 8:41 a.m. - There are some very difficult decisions awaiting the Cowboys on Tuesday, and they have only until 4 p.m. In the absence of Barr, it's been rookie fifth-round pick Damone Clark seeing a surge in reps following his return from neck surgery. He won't play in that contest, as the Titans have the AFC South wrapped up, but he could return for the Divisional Round if the Titans earn the No. J Natl Cancer Inst 2004; Fizazi K, Carducci M, Smith M et al: Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study. Pomerantz MM, Spisk S, Jia L et al: The association between germline BRCA2 variants and sensitivity to platinum-based chemotherapy among men with metastatic prostate cancer. Hes going to be really good, San Antonio guard Devin Vassell said. Patients who received docetaxel plus prednisone every three weeks in TAX-327 had significantly better survival than those receiving mitoxantrone (HR for death: 0.76; p=0.009). So, we got a lot of good snaps for those guys both in our practice session as well as all the preseason games for the most part. Smith appears to be the leading candidate to replace left tackle Tyron Smith (hamstring) in the starting lineup Sept. 11 against the Bucs. 8:40 p.m. - With no Jayron Kearse on the field against the Bengals, the veteran safety sidelined with a knee injury suffered in Week 1, the expectation was the Cowboys would deploy second-year talent Israel Mukuamu and impressive undrafted rookie Markquese Bell in sort of a two-for-one deal to replace the production of Kearse; but it was Donovan Wilson who stole the show at the position. Prostate Cancer Prostatic Dis 2012; Zaheer S, LeBoff M, Lewiecki EM: Denosumab for the Treatment of Osteoporosis. Alexander-Arnold played the remainder of the first half after an inversion ankle sprain midway through, but swelling and pain prevented him from coming out for the second half at Arsenal. About Advertising Contact Privacy Terms, Nunez return & injury updates 4 key things from Jurgen Klopps post-Lyon press conference, Jurgen Klopp admits new Luis Diaz injury is proper smash in the face, Going to be special Liverpool fans impressed by youngster in Lyon defeat, Jurgen Klopp gives Harvey Elliott injury update after early substitution, Liverpool 1-3 Lyon: Reds defeated as 24 players feature in friendly, Elliott injury worry & returning faces 5 talking points from Liverpool 1-3 Lyon, Liverpool FC and the lure no other club can offer, The 6-figure Liverpool signings who could save the club millions, Being a Liverpool fan today and the value of taking a step back. In a similar boat to Keita with his return recently described as still a little bit away, November looks a more likely timeframe than October, which was a tentative date of return. WebFor verification and password recovery . 2017; Picchio M, Spinapolice EG, Fallanca F et al: [11C]Choline PET/CT detection of bone metastases in patients with PSA progression after primary treatment for prostate cancer: comparison with bone scintigraphy. --------------------------------------- Aug. 29 UpdatesMichael Gallup. Jan. 22: Henry rushes for 62 yards and a touchdown on 20 carries against the Bengals. 2 jersey. N Engl J Med. Cancer 2005; Cosman F, de Beur SJ, LeBoff MS et al: National Osteoporosis Foundation. AR-V7 has been investigated as a biomarker of possible benefit from sequential ART therapies. It wasn't clear exactly which play Henry was injured on during his outing against the Colts. As for Lewis himself,, who is coming off of a career-best season in most categories, it's about ramping back up quickly to prepare himself for a battle with Brady and a stable of offensive weapons. Lancet Oncol 2015; Ryan CJ, Smith MR, de Bono JS et al: Abiraterone in metastatic prostate cancer without previous chemotherapy. --------------------------------------- Sept. 8 UpdatesMichael Gallup. This year, a player can be elevated up to three times and return to the practice squad following the game. Out since: Arsenal (A) Out since: Arsenal (A) Prostate Cancer Prostatic Dis 2012; Parker CC, James ND, Brawley CD et al: Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial. ------------------------------------ Dec. 2 UpdatesTrevon Diggs, Height: 6-2Weight: 195 lbsCollege: Alabama. 10:35 a.m. - There's a great chance you'll see Jourdan Lewis on the field when the Cowboys host Tom Brady and the Tampa Bay Buccaneers in the regular season opener at AT&T Stadium on Sunday, Sept. 11. "That's my goal every year - to get that job. Docetaxel is an effective option in both mCRPC and mHSPC and should be considered as standard first-line chemotherapy in the setting of mCRPC.19,20 Cabazitaxel was approved as second line chemotherapy in 2010 based on the results of the TROPIC trial.24 TROPIC randomized 755 men with mCRPC who had previously received docetaxel chemotherapy and demonstrated median survival of 15.1 months (95%CI 14.1 to 16.3) in the cabazitaxel group and 12.7 months (11.6 to 13.7) in the mitoxantrone group. Injury: Hamstring "Doing very well," said McCarthy. Lancet Oncol 2019; Armstrong AJ, Halabi S, Luo J et al: Prospective multicenter validation of androgen receptor splice variant 7 and hormone therapy resistance in high-risk castration-resistant prostate cancer: the PROPHECY study. Injury risk: Low Analysis of other secondary endpoints, such as decreased risk of radiographic progression or death, favored enzalutamide with a 76% risk reduction (HR= 0.24; 95%CI 0.10 to 0.56). 2012; Bryce AH, Alumkal JJ, Armstrong A et al: Radiographic progression with nonrising PSA in metastatic castration-resistant prostate cancer: post hoc analysis of PREVAIL. My whole entire life Ive played 30 minutes (a game), Chandler said. Jan. 20: Mike Vrabel says a final decision on Henry's status will be made on Friday. None of these agents have been studied without ADT for mHSPC, while compelling evidence of survival has been demonstrated with testosterone suppression in combination with either abiraterone acetate plus prednisone, enzalutamide, or apalutamide.28,85,87,89,102,103For now, however, these next generation antiandrogens should not be considered without ADT in mHSPC. McCarthy will also sit down with Beckham as well, as will owner and general manager Jerry Jones, the latter having been in continuous contact with the two-time All-Pro wide receiver. N Engl J Med 2018; Fizazi K, Shore N, Tammela TL et al: Darolutamide in nonmetastatic, castration-resistant prostate cancer. 2015; Onstenk W, Sieuwerts AM, Kraan J et al: Efficacy of cabazitaxel in castration-resistant prostate cancer is independent of the presence of AR-V7 in circulating tumor cells. Median OS was not reached in the apalutamide group versus 39.0 months in the placebo group (HR=0.70; 95%CI 0.47 to 1.04; p=0.07). Tarell Basham was initially ruled out as well but having now been moved to IR for the signing of Cooper Rush to the active roster negates the need to list him as inactive, and it is instead linebacker Jabril Cox joining Tolbert in not suiting up for a second consecutive game as he continues to ramp up from a torn ACL suffered in 2021; and cornerback Nahshon Wright rounds out the list. WebFind all the latest real-time sports coverage, live reports, analysis and comment on Telegraph Sport. Adverse events of grade 3 or higher occurred in 56.3% of patients receiving cabazitaxel and in 52.4% of those receiving an androgen-signaling-targeted inhibitor. Nature 2012; Sonnenblick A, de Azambuja E, Azim HA Jr et al: An update on PARP inhibitors--moving to the adjuvant setting. That entailed working withTitans trainers "on a daily basis" to speed up his recovery, asNFL Network's Ian Rapoport reported in mid-December. J Natl Compr Canc Netw 2013; Greenspan SL, Coates P, Sereika SM et al: Bone loss after initiation of androgen deprivation therapy in patients with prostate cancer. Eur Urol 2019; Kane CJ, Amling CL, Johnstone PA et al: Limited value of bone scintigraphy and computed tomography in assessing biochemical failure after radical prostatectomy. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Lewis has not gone on short-term injured reserve, though, which indicates the Cowboys are optimistic he won't miss much more time. J Urol 2018; Smith MR, Saad F, Oudard S et al: Denosumab and bone metastasis-free survival in men with nonmetastatic castration-resistant prostate cancer: exploratory analyses by baseline prostate-specific antigen doubling time. Password: Password requirements: 6 to 30 characters long; ASCII characters only (characters found on a standard US keyboard); must contain at least 4 different symbols; at least 1 number, 1 uppercase and 1 lowercase letter; not based on your username or email address. In the absence of prospective data demonstrating that surgery leads to an oncologic benefit in men with metastatic prostate cancer, its use should be restricted to clinical trials. He hadn't endured many injury problems during the early stages of his career, but would that change as he inched closer and closer to 1,500 career carries? JAMA Oncol 2019; Marcus L, Lemery SJ, Keegan P et al: FDA approval summary: pembrolizumab for the treatment of microsatellite instability-high solid tumors. Both returned to practice on Friday, however, and though it was in a limited capacity, it supports the expectation that they'll take the field in Week 13 - along with Diggs saying he "feels a lot better" than earlier in the week - while DeMarcus Lawrence is a full-go with injury designation at all on Friday. Urology 2003; Seltzer MA, Barbaric Z, Belldegrun A et al: Comparison of helical computerized tomography, positron emission tomography and monoclonal antibody scans for evaluation of lymph node metastases in patients with prostate specific antigen relapse after treatment for localized prostate cancer. Mike McCarthy praised not only Armstrong, who is second on the team with eight sacks, but the Cowboys' scouting and coaching staff for developing him from a fourth-round pick in 2018. Urology 2010; Kunath F, Grobe HR, Rucker G et al: Non-steroidal antiandrogen monotherapy compared with luteinizing hormone-releasing hormone agonists or surgical castration monotherapy for advanced prostate cancer: a Cochrane systematic review. N Engl J Med 2005; Lassemillante AC, Doi SA, Hooper JD et al: Prevalence of osteoporosis in prostate cancer survivors: a meta-analysis. Bucs star wide receiver Chris Godwin is active for Tampa after having limited practice time during the week in his return from January knee surgery. 4:27 p.m. - Rookie Tyler Smith has received praise for his NFL debut at left tackle against the Bucs, but the first-round draft pick wants to build on those 69 snaps heading into this Sunday's game against Cincinnati. J Urol 2018; Sweeney CJ, Chen YH, Carducci M et al: Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. Other multiple numbers include No. 10:42 a.m. - The Cowboys drafted a receiver in the third round to provide immediate help to a position of need. He's so consistent. 2 quarterback behind starter Dak Prescott. Out since: September 7 Median PFS was 40.5 months in the apalutamide group versus 14.7 months in the placebo group (HR=0.29; 95%CI 0.24 to 0.36; P<0.001). But backup Will Grier shouldn't be dismissed in the equation. In a phase III, double-blind, placebo-controlled trial, Saad et al.147randomized patients with mCRPC to receive zoledronic acid at 4 mg or placebo every 3 weeks for 15 months; the primary endpoint was the proportion of men experiencing at least 1 SRE. --------------------------------------- Tyler Smith. The rate of pathologic fractures was also lower compared to placebo (13.1% with zoledronic acid versus 22.1% for placebo). 10:22 a.m. - The impact of adding Jason Peters to the roster is already being felt by the Cowboys, and before he's had a chance to take a single snap for the team. Yonsei Med J 2015; Nakabayashi M, Hayes J, Taplin ME et al: Clinical predictors of survival in men with castration-resistant prostate cancer: evidence that Gleason score 6 cancer can evolve to lethal disease. "I know he had really good work last week with [Cowboys trainer Britt Brown]," said McCarthy. Cancer 2013; Mateo J, Carreira S, Sandhu S et al: DNA-repair defects and olaparib in metastatic prostate cancer. Thursday was his first padded practice since the injury. 1:59 p.m. - It's almost time for kickoff in the coming matchup between the Cowboys and the Bengals, and that means both teams have to decide which players won't suit up in Week 2 - instead being inactive for the contest. It is Matips second injury absence of the season after missing the clashes against Crystal Palace, Man United and Bournemouth. 11:30 a.m. - With two seats still vacant on the practice squad, the Cowboys made moves to fill them - adding an offensive lineman and a running back to the mix. 12:33 p.m. - All indications point towards Cooper Rush getting the start this Sunday in place of Dak Prescott. The Panel does not recommend the use of abiraterone acetate plus prednisone for men with nmCRPC because of other options and lack of an FDA-approved indication for this clinical space. Its the first time Ive ever dealt with this. At the time of planned interim analysis, the median OS was 18.4 months in the enzalutamide group versus 13.6 months in the placebo group (HR for death in the enzalutamide group= 0.63; 95%CI 0.53 to 0.75; P<0.001). Sipuleucel-T immunotherapy is an FDA-approved agent in this setting based upon the results of the IMPACT trial,23 published in 2010. Jan. 3: Mike Vrabel says that Henry's practice window could open ahead of Week 18. 11:18 a.m. - On a defense that has Micah Parsons, Trevon Diggs and DeMarcus Lawrence, getting overlooked is expected. With the Cowboys leading 21-19 and the Colts looking to tie it up with a two-point conversion, Bland broke up a pass at the goal line to keep the Cowboys in the lead and the rout was on after that. Other PARP inhibitors (e.g., niraparib, veliparib, talozaparib) are currently under investigation. Desmond Bane will miss at least three to four more weeks with a toe injury he suffered last month, the Grizzlies announced. If he crosses that hurdle today, then hopefully we'll do more next week," McCarthy said. 3:26 p.m. - The feel in the air is that Jourdan Lewis will, in fact, be on the field when the Cowboys host the Tampa Bay Buccaneers at AT&T Stadium on Sept. 11 - barring any unexpected setbacks. Clin Cancer Res 2007; Pond GR, Sonpavde G, de Wit R et al: The prognostic importance of metastatic site in men with metastatic castration-resistant prostate cancer. Am J Prev Med 2001; Shea BJ, Reeves BC, Wells G et al: AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. ------------------------------------ Dak Prescott, Height: 6-2Weight: 238 lbsCollege: Mississippi State. We need to get past these seven days, then we'll have a better idea.". The study concluded that early treatment with zoledronic acid in men with HSPC and bone metastases was not associated with lower risk for SREs or death. It is worth noting that patients receiving sipuleucel-T therapy rarely (<10%) exhibit a clinical, serologic or radiographic response, and, as such, should be counseled appropriately not to expect to see a decline in PSA or reduction in radiologic volume of disease when undergoing this treatment. Out since: Arsenal (A) "We've got to be better there. J Clin Oncol 2006; Harshman LC, Chen YH, Liu G et al: Seven-month prostate-specific antigen is prognostic in metastatic hormone-sensitive prostate cancer treated with androgen deprivation with or without docetaxel. Wilson finished the fight with the Bengals as team leader in tackles, eight in all with six of them solo, and several of them were timely in shutting down critical third-down attempts by Burrow and the Bengals offense. Neither practiced on Wednesday due to it, and they won't be on the field for Thursday's practice either. J Clin Oncol 2016; Gratzke C, Engel J, Stief CG: Role of radical prostatectomy in metastatic prostate cancer: data from the Munich Cancer Registry. The MMR system is a post-replicative, single-strand repair mechanism that recognizes and reverses DNA base mismatches and insertions/deletions. J Clin Oncol 2019; Chi KN, Protheroe A, Rodriguez-Antolin A et al: Patient-reported outcomes following abiraterone acetate plus prednisone added to androgen deprivation therapy in patients with newly diagnosed metastatic castration-naive prostate cancer (LATITUDE): an international, randomised phase 3 trial. "Grier got slowed there right at the end with a hamstring issue. "I don't have anything definitive there," he told 105.3FM the Fan. Time to first skeletal-related event (SRE) improved from 9.8 month with placebo to 15.6 months with radium-223 (HR=0.66; 95%CI 0.52 to 0.83; P<0.001). Injury: Calf His lateral ankle ligaments will be the concern but the hope is he has avoided serious injury and could be sidelined for between two to three weeks, report the Times. In speaking with 105.3 The Fan on Tuesday, chief operating officer Stephen Jones didn't rule out the possibility of the latter being in consideration - also making clear that both Rush and Grier have the inside track. Expected return: November. To date, there is little prospective randomized data evaluating PET as a staging study for untreated prostate cancer, mHSPC or CRPC.161 While studies are being completed to generate data for FDA registration based on safety and performance, what will ultimately determine the role of these PET agents will be trials demonstrating improved patient outcomes as a direct result of earlier intensification of systemic therapies, MDT, and/or prediction of responses to specific therapies. "If you're doing it the first game of a long season - that's stupid. The CARD trial126tested the efficacy and safety of cabazitaxel versus the alternative ART therapy in patients with mCRPC who progressed after two prior therapies. Damone Clark is currently on NFI (Non-Football Injury) and the rest of the class is on the active roster. J Clin Oncol 2013; Howard LE, Moreira DM, De Hoedt A et al: Thresholds for PSA doubling time in men with non-metastatic castration-resistant prostate cancer. Originally listed as doubtful for Tuesday vs. Sacramento, Morant has been upgraded to questionable, the Grizzlies announced this morning (via Twitter). Kicker Brett Maher and backup quarterback Cooper Rush were elevated Saturday from the practice squad and are active against the Bucs. 2018; Antonarakis ES, Lu C, Wang H et al: AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. As expected, the Cowboys re-signed both to the team's 17-man practice squad as they continue to finalize their roster, but McCarthy has already penciled in who'll be on the sideline in Week 1. Instead, Gallup is allowed to begin practicing with the team as soon as he receives complete medical clearance, having already passed his physical on Tuesday. 1 seed in the divisional round. 1000 Corporate Boulevard Linthicum, MD 21090 Phone: 410-689-3700 Toll-Free: 1-800-828-7866 Fax: 410-689-3800 Email: aua@AUAnet.org. JAMA 2017; Smith MR, Halabi S, Ryan CJ et al: Randomized controlled trial of early zoledronic acid in men with castration-sensitive prostate cancer and bone metastases: results of CALGB 90202 (alliance). Both arms remained on ADT. BMC Cancer 2017; Jackson WC, Suresh K, Tumati V et al: Impact of biochemical failure after salvage radiation therapy on prostate cancer-specific mortality: competition between age and time to biochemical failure. The hamstring (injury) really played a factor in this. But if Dorance Armstrong is getting overshadowed by fans and media, that's not the case for his head coach. N Engl J Med 2012; Tunn UW, Canepa G, Kochanowsky A et al: Testosterone recovery in the off-treatment time in prostate cancer patients undergoing intermittent androgen deprivation therapy. J Urol 2021; Study limitations, based on the overall risk of bias across studies (low, medium, or high) and the seriousness of methodological limitations, Consistency of results across studies (consistent, inconsistent, or unable to determine when only one study was available), Directness of the evidence linking the intervention and health outcomes (direct or indirect), Precision of the estimate of effect, based on the number and size of studies and confidence intervals for the estimates (precise or imprecise), Reporting bias, based on whether the studies defined and reported primary outcomes and whether we identified relevant unpublished studies (suspected or undetected). A SEER-based study. 2:45 p.m. - After sitting out last week with a sprained ankle, rookie offensive lineman Tyler Smith was practicing again during the portion open to the media on Wednesday. With Ja Morant sidelined on Monday due to left ankle soreness, Tyus Jones showed why the Grizzlies made him the NBAs highest-paid backup point guard this past summer, writes Damichael Cole of The Memphis Commercial Appeal.Inserted into the starting lineup, Jones responded by scoring 28 points and dishing out 10 assists en route This allows clinicians to monitor disease status and should be performed every three to six months. Here's the full Cowboys' inactive list for Sunday: wide receiver Michael Gallup (knee), who was ruled out on Friday; linebacker Jabril Cox; rookie wide receiver Jalen Tolbert; cornerback Nahshon Wright; safety Markquese Bell; rookie defensive tackle John Ridgeway; and safety Israel Mukuamu. Even when Kearse is on the field, the Cowboys often deployed three-safety sets in Week 1 that allowed Wilson to play alongside Malik Hooker and it proved to be an effective strategy in flummoxing and otherwise unshakable Brady - who showed signs of frustration at times in being unable to capitalize on drives with touchdowns, instead often settling for field goals. Four more weeks with a hamstring issue the clashes against Crystal Palace, Man United and Bournemouth previous. I do n't have anything definitive there, '' he told 105.3FM the Fan talozaparib ) are under! A position of need how this week 's inactives by Will Grier should n't be on the roster! Grizzlies announced et al: Darolutamide in nonmetastatic, castration-resistant prostate cancer trainer Brown. De Bono JS et al: ar-v7 and resistance to enzalutamide and Abiraterone in prostate cancer says that Henry practice! N'T be on the verge of returning after missing only Sundays game in Brooklyn but... 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